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Nexium (Esomeprazole) additional information

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Nexium, common uses

Nexium is indicated for the short-term treatment (4 to 8 weeks) in the healing and symptomatic resolution of diagnostically confirmed erosive esophagitis. For those patients who have not healed after 4-8 weeks of treatment, an additional 4-8-week course of Nexium may be considered.

Nexium is as well indicated to maintain symptom resolution and healing of erosive esophagitis. Controlled studies do not extend beyond 6 months. Nexium is also indicated for treatment of heartburn and other symptoms associated with GERD.

Nexium, directions

Nexium is supplied as tablets for oral administration. Each tablet contains 40 mg. of esomeprazole, to take by mouth.

The recommended adult dosages are very between 20 to 40 mg. daily. Nexium tablets should be swallowed whole and taken at least one hour before eating.

Nexium, precautions

There are no adequate and well-controlled studies in pregnant women. Nexium should be used during pregnancy only if clearly needed. Because esomeprazole is likely to be excreted in human milk and because of the potential for serious adverse reactions in nursing infants from esomeprazole a decision should be made whether to discontinue nursing or to discontinue Nexium, taking into account the importance of Nexium to the mother.

Esomeprazole inhibits gastric acid secretion. Therefore, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts and digoxin).

Nexium, possible side effects

Possible side effects from the use of Nexium include, enlarged abdomen, allergic reaction, asthenia, back pain, chest pain, fatigue, fever, flu-like disorder, generalized edema, leg edema, malaise, hypertension, bowel irregularity, dyspepsia, dysphagia, epigastric pain, eructation, esophageal disorder, tongue disorder, tongue edema, ulcerative stomatitis, earache, tinnitus, anemia, cervical lymphoadenopathy, epistaxis, leukocytosis, leukopenia, bilirubinemia, hepatic function abnormal, glycosuria, hyperuricemia, hyponatremia, increased alkaline phosphatase, thirst, vitamin B12 deficiency, weight change, arthralgia, arthropathy, cramps, fibromyalgia syndrome, hernia, apathy, confusion, dizziness, hypertonia, nervousness, hypoesthesia, insomnia, migraine, somnolence, tremor, vertigo, acne, angioedema, dermatitis, pruritus, pruritus ani, rash, taste loss, abnormal urine, abnormal vision.

Nexium, overdose

Manifestations from an overdose of Nexium may be variable, but include confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache and dry mouth.

Nexium is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles. Clarithromycin is contraindicated in patients with a known hypersensitivity to any macrolide antibiotic. Amoxicillin is contraindicated in patients with a known hypersensitivity to any penicillin.

If overdose of Nexium is suspected, contact your local poison control center or emergency room immediately.

Nexium, additional information

Keep Nexium in a tightly closed container and out of reach of children. Store Nexium at room temperature and away from excess heat and moisture (not in the bathroom).


The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. It should not be construed to indicate that use of Nexium is safe, appropriate, or effective for you.
Consult your health care professional before you buy Nexium (Esomeprazole).

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