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Celebrex (Celecoxib) additional information

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Celebrex, common uses

Celebrex is a nonsteroidal anti-inflammatory drug that exhibits anti-inflammatory analgesic and antipyretic activities. The mechanism of action of Celebrex is believed to be due to inhibition of prostaglandin synthesis.

Celebrex, directions

Celebrex comes as a capsule, containing 200 mg. celecoxib, to take by mouth.

Celebrex is indicated for relief of the signs and symptoms of osteoarthritis. Celebrex is also indicated for the relief of the signs and symptoms of rheumatoid arthritis in adults.

The lowest dose of Celebrex should be sought for and for relief of the signs and symptoms of osteoarthritis the recommended oral dose is 200 mg. per day administered as a single dose or as 100 mg. twice per day.

For relief of the signs and symptoms of rheumatoid arthritis the recommended oral dose is 100 to 200 mg. twice per day.

If you miss a dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Celebrex, precautions

Serious gastrointestinal toxicity such as bleeding, ulceration, and perforation of the stomach, small intestine or large intestine can occur at any time, with or without warning symptoms, in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Minor upper gastrointestinal problems, such as dyspepsia, are common and may also occur at any time during NSAID therapy. It has been demonstrated that upper GI ulcers, gross bleeding or perforation, caused by NSAIDs, appear to occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year. However, even short term therapy is not without risk.

NSAIDs should be used with extreme caution by individuals with a prior history of ulcer disease or gastrointestinal bleeding. Most spontaneous reports of fatal GI events are in elderly or debilitated individuals. To minimize the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration. For high risk patients, alternate therapies that do not involve NSAIDs should be considered.

In late pregnancy Celebrex should be avoided because celecoxib may cause premature closure of the ductus arteriosus.

The pharmacological activity of Celebrex in reducing inflammation, and possibly fever, may diminish the utility of these diagnostic signs in detecting infectious complications of presumed noninfectious, painful conditions.

If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc.), Celebrex should be discontinued.

Long term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Individuals at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly.

Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Clinical trials with Celebrex have shown renal effects similar to those observed with comparator NSAIDs.

Caution should be used when initiating treatment with Celebrex in individuals with considerable dehydration. It is advisable to rehydrate first and then start therapy with Celebrex. Caution is also recommended in individuals with pre-existing kidney disease.

There are no studies of the effects of Celebrex in pregnant women. Celebrex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Celebrex, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Caution should be used when administering Celebrex with warfarin since these individuals are at increased risk of bleeding complications.

Celebrex, possible side effects

The most common side effects of the treatment of Celebrex include abdominal pain, diarrhea, dyspepsia, flatulence, nausea, back pain, peripheral edema, dizziness, headache, insomnia, pharyngitis, rhinitis, sinusitis, upper resp. tract infection and skin rash.

If you notice other effects not listed above, contact your doctor.

Celebrex, overdose

If overdose of Celebrex is suspected, contact your local poison control center or emergency room immediately.

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.

Celebrex, additional information

Keep Celebrex in a tightly closed container and out of reach of children. Store Celebrex at room temperature and away from excess heat and moisture (not in the bathroom).

Note

The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. It should not be construed to indicate that use of Celebrex is safe, appropriate, or effective for you.
Consult your health care professional before you buy Celebrex (Celecoxib).

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